IL-21 Receptor Modulates Ischemic Severity in Stroke
نویسندگان
چکیده
منابع مشابه
IL 21 R ( interleukin 21 receptor )
The IL21R gene is comprised of 9 exons (+2 alternative first exons), spanning 48.4kb on chromosome 16p11 (Parrish-Novak, 2000). The human IL21R promoter region, contained within nucleotides -789 to +195 (relative to the start of exon 1a) induces the high levels of transcription in reporter assays (Ueda, 2002). A critical SP1 binding site is contained in the region from -80 to -20 and is essenti...
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published from 2007 onward [7]. On the other hand, the results cited in the article appear to have been muddled. Thus, a study by Flex et al. [8] refers to an entirely different phenotype of peripheral artery occlu-sive disease (only 22 patients actually also had a history of stroke). Assuming that the authors had intended to refer to another study by the same author [9] , we face the obvious o...
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The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role. Increasing evidence points toward an early inflammatory infiltrate and associated inflammatory cytokine production in human and animal models of tendon disease. The IL-21/IL-21R axis is a proinflammatory cytokine complex that has been associated ...
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Ischemic stroke is a leading cause of morbidity and mortality in the US; however, there currently exists only one effective acute pharmacological therapeutic intervention. Purinergic signaling has been shown to regulate vascular function and pathological processes, including inflammation and arterial myogenic reactivity, and plays a role in ischemic stroke outcome. Purinergic signaling requires...
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ژورنال
عنوان ژورنال: Neurosurgery
سال: 2016
ISSN: 0148-396X
DOI: 10.1227/01.neu.0000508602.53941.4e